Febuxostat methanol solvate C16H16N2O3S·CH4O
2011
Crystal Structure of Febuxostat Methanol Solvate
publication
Evidence: moderate
Author Information
Author(s): Jiang Qi-Ying, Qian Jing-Jing, Gu Jian-Ming, Tang Gu-Ping, Hu Xiu-Rong
Primary Institution: Zhejiang University
Hypothesis
The study aims to report the crystal structure of febuxostat methanol solvate.
Conclusion
The crystal structure reveals that febuxostat and methanol molecules are linked by hydrogen bonds into helical chains.
Supporting Evidence
- The benzene and thiazole rings in the febuxostat molecule are twisted at 5.3°.
- Intermolecular hydrogen bonds link febuxostat and methanol into helical chains.
- The study provides insights into the structural properties of febuxostat in a methanol environment.
Takeaway
This study looks at how febuxostat, a medicine for gout, forms a specific structure when mixed with methanol.
Methodology
The crystal structure was determined using X-ray diffraction techniques.
Digital Object Identifier (DOI)
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