Apolipoprotein E Genetic Polymorphism and Stroke Subtypes in Bangladesh
Author Information
Author(s): Chowdhury Anisul Haque, Yokoyama Tetsuji, Kokubo Yoshihiro, Zaman Mohammad Mostafa, Haque Anisul, Tanaka Heizo
Primary Institution: Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
Hypothesis
The apoE genetic polymorphism is related to stroke differently according to its subtypes.
Conclusion
Carriers of the apoE ε4 allele are at a higher risk of developing thrombotic stroke in the cortical artery territory, while ε2 carriers have an increased risk of hemorrhagic stroke in the elderly.
Supporting Evidence
- ε4 carriers had approximately 3-fold increased risk of cortical thrombosis.
- ε2 carriers were associated with a risk of hemorrhagic stroke in the elderly.
- The study is the first of its type in South Asian countries.
Takeaway
This study found that certain genes can make people more likely to have different types of strokes, especially in older people.
Methodology
A case-control study involving first-ever-stroke patients and controls, with stroke diagnosis based on CT and clinical findings.
Potential Biases
Potential bias due to the selection of controls from a specific patient group (cataract patients).
Limitations
The control group was selected from cataract patients, which may introduce bias, and the sample size for some analyses was small.
Participant Demographics
First-ever-stroke patients from a Bangladeshi hospital, average age around 57.9 years.
Statistical Information
P-Value
p=0.02
Confidence Interval
95% CI 1.2 to 10.4 for ε3/ε4 genotype and 95% CI 1.3 to 295.2 for ε2 carrier in elderly.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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