Methods in causal inference. Part 4: confounding in experiments
2024

Understanding Confounding Bias in Experiments

publication Evidence: high

Author Information

Author(s): Bulbulia Joseph A.

Primary Institution: Victoria University of Wellington, Wellington, New Zealand

Hypothesis

Does randomisation eliminate all systematic causes of treatment assignment and outcome?

Conclusion

Confounding biases can still occur in randomised experiments even when randomisation is successful.

Supporting Evidence

  • Randomisation does not prevent confounding bias from post-treatment adjustments.
  • Causal directed acyclic graphs help identify sources of bias in experimental designs.
  • Confounding biases can arise even in well-designed randomised controlled trials.

Takeaway

Even when experiments are set up correctly, there can still be hidden problems that affect the results. It's important to be careful about how we design and analyze these experiments.

Methodology

The paper uses causal directed acyclic graphs to illustrate sources of confounding bias in randomised controlled trials.

Potential Biases

Post-treatment selection and conditioning can introduce confounding bias.

Limitations

The examples presented do not cover all potential biases in causal inference.

Digital Object Identifier (DOI)

10.1017/ehs.2024.34

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