Fusobacterium nucleatum and Colorectal Cancer Liver Metastasis
Author Information
Author(s): Yu Yulong, Yin Han, Wu Bili, Zhao Weiheng, Wang Yuan, Aili Aifeina, Yang Mu, Yu Qianqian
Primary Institution: Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Hypothesis
Does Fusobacterium nucleatum promote colorectal cancer liver metastasis through the miR-5692a/IL-8 axis?
Conclusion
Fusobacterium nucleatum promotes colorectal cancer liver metastasis by inducing epithelial-mesenchymal transition through the miR-5692a/IL-8 axis.
Supporting Evidence
- Fusobacterium nucleatum was found in high abundance in colorectal cancer tissues.
- Co-culture with F. nucleatum significantly enhanced the metastasis ability of CRC cells.
- F. nucleatum infection increased IL-8 expression by downregulating miR-5692a.
Takeaway
Fusobacterium nucleatum is a bacteria that can make colorectal cancer spread to the liver by changing how cancer cells behave.
Methodology
The study used in vitro assays, a mouse model for liver metastasis, transcriptome sequencing, qRT-PCR, and Western Blot assays to evaluate the effects of F. nucleatum on CRC cells.
Limitations
The study lacks data from human specimens to confirm the findings.
Participant Demographics
Male BALB/C mice were used for the in vivo experiments.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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