Suppressing Breast Tumor Growth with an Engineered Transcription Factor
Author Information
Author(s): Adriana S. Beltran, Angela Russo, Haydee Lara, Cheng Fan, Paul M. Lizardi, Pilar Blancafort
Primary Institution: University of North Carolina at Chapel Hill
Hypothesis
Can the Artificial Transcription Factor 126 (ATF-126) inhibit tumor progression in pre-established breast tumors?
Conclusion
The study found that ATF-126 significantly reduced tumor growth and prevented metastasis in breast cancer models.
Supporting Evidence
- ATF-126 induced a 50% reduction in tumor growth in mice.
- Induction of ATF-126 abolished tumor cell colonization in the lungs.
- Genome-wide analysis revealed a 550-gene signature associated with favorable prognosis.
Takeaway
Scientists created a special tool to help stop breast cancer from growing and spreading, and it worked really well in mice.
Methodology
The study used an inducible viral vector system to control ATF-126 expression in breast cancer cells implanted in immunodeficient mice.
Limitations
The study was conducted in immunodeficient mice, which may not fully represent human responses.
Participant Demographics
Immunodeficient mice were used for the experiments.
Statistical Information
P-Value
0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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