A Unique Case of Malignant GIST in the Gallbladder
Author Information
Author(s): Athanasios Petrou, Pari Alexandrou, Alexandros Papalambros, Angelica Saetta, Paraskevi Fragkou, Michalis Kontos, Nicholas Brennan, Antonio Manzelli, Kostantinos Bramis, Evangelos Felekouras
Primary Institution: University of Athens
Hypothesis
This study presents a unique case of a malignant gastrointestinal stromal tumor (GIST) of the gallbladder that is immunoreactive for PDGFRA and negative for CD 117 antigen.
Conclusion
The case highlights the challenges in diagnosing and managing a rare type of GIST that is negative for the common CD 117 marker.
Supporting Evidence
- GISTs of the gallbladder are extremely rare, with only seven reported cases.
- This case is the first documented instance of a gallbladder GIST that is negative for CD 117 and positive for PDGFRA.
- The tumor exhibited a high mitotic rate, which places it in a high-risk group for recurrence.
Takeaway
This study talks about a rare tumor in the gallbladder that usually shows a specific marker but in this case, it didn't, which makes it special.
Methodology
The study involved a case report of a 72-year-old woman with a gallbladder tumor, including clinical examination, imaging, surgical intervention, and pathological analysis.
Limitations
The study is based on a single case report, limiting the generalizability of the findings.
Participant Demographics
The participant was a 72-year-old woman.
Digital Object Identifier (DOI)
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