Inflammatory Response and Survival in Breast Cancer
Author Information
Author(s): Murri AM Al, Hilmy M, Bell J, Wilson C, McNicol A-M, Lannigan A, Doughty J C, McMillan D C
Primary Institution: University Department of Surgery, University of Glasgow
Hypothesis
The study examines the relationship between systemic inflammatory response, tumor characteristics, and survival in patients with primary operable breast cancer.
Conclusion
The study found that host inflammatory responses are closely associated with poor tumor differentiation, proliferation, and malignant disease progression in breast cancer.
Supporting Evidence
- Increased tumor grade and proliferative activity were associated with greater tumor T-lymphocyte and macrophage infiltration.
- On univariate analysis, increased lymph-node involvement and lower albumin concentrations were associated with cancer-specific survival.
- Only tumor microvessel density was independently associated with poorer cancer-specific survival.
Takeaway
This study shows that inflammation in the body can affect how well breast cancer patients do after treatment.
Methodology
The study used immunohistochemistry and slide-counting techniques to analyze tumor samples from patients with primary operable breast cancer.
Limitations
The study had a relatively limited number of events and a relatively short follow-up period.
Participant Demographics
81% of patients were over 50 years old, and 29% were in the most deprived categories.
Statistical Information
P-Value
P<0.01
Confidence Interval
95% CI 1.35–16.85
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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