Immunoparalysis Biomarkers in Sepsis and Critical Illness
Author Information
Author(s): Samuelsen Abigail, Lehman Erik, Burrows Parker, Bonavia Anthony S.
Primary Institution: Penn State Medical Center
Hypothesis
Patterns of ex vivo-stimulated cytokine release would mirror the trajectories of mHLA-DR expression and ALC over time.
Conclusion
The study found that immune function in critically ill patients varies significantly over the first two weeks following the onset of sepsis.
Supporting Evidence
- mHLA-DR expression significantly increased over time, primarily in non-septic patients.
- ALC recovery was more pronounced in septic patients.
- Ex vivo stimulation revealed significant increases in TNF and IL-6 production over time.
Takeaway
This study looked at how the immune system works in very sick patients over two weeks, finding that some immune markers change a lot, especially in those with sepsis.
Methodology
The study compared cytokine release from whole blood of critically ill patients to traditional markers of immunoparalysis over two weeks.
Potential Biases
The use of corticosteroids may have influenced the observed immune responses.
Limitations
The study design did not allow for the assessment of the functional capacity of immune cells beyond cytokine production.
Participant Demographics
64 critically ill patients, including 31 septic and 33 non-septic patients.
Statistical Information
P-Value
p = 0.002
Confidence Interval
95% CI 0.072 - 0.259
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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