Daptomycin's Effectiveness Against Resistant Bacteria in Europe
Author Information
Author(s): Helio Sader, Amy A. Watters, Thomas R. Fritsche, Ronald N. Jones
Primary Institution: JMI Laboratories, North Liberty, Iowa, USA
Hypothesis
How effective is daptomycin against methicillin-resistant staphylococci and vancomycin-resistant enterococci in European medical centers?
Conclusion
Daptomycin showed excellent in vitro activity against staphylococci and enterococci collected in European medical centers in 2005, with resistance to other antibiotics not compromising its effectiveness.
Supporting Evidence
- Daptomycin was 100% effective against all tested S. aureus strains.
- Resistance rates for oxacillin among S. aureus varied significantly by country.
- Daptomycin showed a MIC50 of 0.25 mg/L for S. aureus and 2 mg/L for E. faecium.
Takeaway
Daptomycin is a strong medicine that works well against certain bad bacteria that are hard to treat, even when those bacteria are resistant to other medicines.
Methodology
The study tested 4,640 strains from 23 medical centers in 10 European countries for susceptibility using broth microdilution methods.
Limitations
The study only reflects data from 2005 and may not represent current resistance patterns.
Participant Demographics
Strains were collected from patients hospitalized in various European medical centers.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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