Thyroid hormone components are expressed in three sequential waves during development of the chick retina
2008
Thyroid Hormone Components in Chick Retina Development
publication
Evidence: moderate
Author Information
Author(s): Trimarchi Jeffrey M, Harpavat Sanjiv, Billings Nathan A, Cepko Constance L
Primary Institution: Harvard Medical School
Hypothesis
Thyroid hormone components are expressed in three sequential waves during the development of the chick retina.
Conclusion
Multiple thyroid hormone components were expressed in dynamic patterns in cycling progenitor cells and photoreceptor cells across the developing chick retina.
Supporting Evidence
- Three waves of thyroid hormone component expression were identified during chick retina development.
- TRb expression was linked to the early stages of photoreceptor cell differentiation.
- Dio3 was expressed throughout the cell cycle in progenitor cells.
Takeaway
The study found that thyroid hormones help control how cells in the chick retina develop over time, showing up in waves as the retina grows.
Methodology
In situ hybridization was used to examine the expression of thyroid hormone components in the chick retina at different developmental stages.
Digital Object Identifier (DOI)
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