Thymidine Phosphorylase in Prostate Cancer
Author Information
Author(s): Sivridis E, Giatromanolaki A, Papadopoulos I, Gatter K C, Harris A L, Koukourakis M I
Primary Institution: Democritus University of Thrace, Alexandroupolis, Greece
Hypothesis
The study investigates the role of thymidine phosphorylase-expressing cells in angiogenesis in prostate adenocarcinomas.
Conclusion
Thymidine phosphorylase is a major angiogenic factor in prostate carcinomas, and its up-regulation is likely linked to a host immune response.
Supporting Evidence
- High thymidine phosphorylase expression in cancer cells was associated with increased angiogenesis.
- Thymidine phosphorylase expression was inversely related to prostate specific antigen reactivity.
- Thymidine phosphorylase expression was linked to the presence of tumor-associated macrophages and tumor-infiltrating lymphocytes.
Takeaway
This study found that a protein called thymidine phosphorylase helps tumors grow new blood vessels in prostate cancer, especially when the body is fighting the cancer.
Methodology
The study analyzed 20 normal/hyperplastic prostate glands and 60 prostate carcinomas using immunohistochemistry to assess thymidine phosphorylase expression.
Participant Demographics
The study included 20 normal/hyperplastic prostate specimens and 60 prostate carcinoma specimens.
Statistical Information
P-Value
p=0.02
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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