Metabolomic Profile and Prostate Cancer Diagnosis
Author Information
Author(s): Salinas Pita Angela Patricia, Mosquera Escudero Mildrey, Jiménez-Charris Eliecer, García-Perdomo Herney Andrés
Primary Institution: Universidad del Valle, Cali, Colombia
Hypothesis
To determine the association of a metabolomic profile with the diagnosis of localized prostate cancer.
Conclusion
Disturbances in the metabolism of fatty acids, amino acids, nucleotides, and steroid hormones were identified, suggesting the presence of localized prostate cancer.
Supporting Evidence
- 14 case-control studies were included in the review.
- Serum was the primary sample used to identify metabolites.
- Low concern was found regarding the application of the index test and reference standard in assessing the risk of bias.
- Metabolites of interest included amino acids, lipids, androgens, estrogens, nucleotides, and histidine metabolism.
Takeaway
Scientists studied different body fluids to find out if certain chemicals can help diagnose prostate cancer better.
Methodology
A systematic review of clinical trials and observational studies was conducted, analyzing metabolite results in various biological samples.
Potential Biases
Some studies had high risk of bias in participant selection and evaluation of the index test.
Limitations
The studies included varied significantly in sample sizes, methodologies, and biomarkers studied, which may affect the generalizability of the findings.
Participant Demographics
The studies included 10,189 men aged 45-85, with some studies also including women for comparison.
Digital Object Identifier (DOI)
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