Effects of Sulphated Polysaccharides on Leukocyte Recruitment
Author Information
Author(s): N. Van Osselaer, A M. Rampart, A. G. Herman
Primary Institution: University of Antwerp (UIA)
Hypothesis
The study investigates how sulphated polysaccharides affect polymorphonuclear leukocyte (PMN) recruitment and plasma leakage in response to inflammatory mediators.
Conclusion
Sulphated polysaccharides significantly inhibit PMN infiltration and plasma leakage in response to certain inflammatory mediators, but not in response to IL-1.
Supporting Evidence
- PMN infiltration was significantly inhibited after intravenous injection of dextran sulphate, heparin, or fucoidan.
- Fucoidan was the only polysaccharide able to suppress IL-1-induced PMN infiltration for 60-70%.
- Dextran sulphate completely abolished PMN infiltration and plasma extravasation in response to PMN chemoattractants.
Takeaway
This study shows that certain sugars can help stop white blood cells from moving into inflamed areas, which might help reduce swelling.
Methodology
The study used a rabbit skin model to measure PMN accumulation and plasma leakage after injecting various inflammatory mediators and sulphated polysaccharides.
Participant Demographics
Male New Zealand White rabbits (2.5-3.5 kg body weight)
Statistical Information
Statistical Significance
p<0.05
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