DNAJC6 Gene Variation and Obesity Risk in Children
Author Information
Author(s): Shin Jieun, Kang Inhae, Lee Myoungsook
Primary Institution: Sungshin Women’s University
Hypothesis
Does variation in the DNAJC6 gene related to resting metabolic rate (RMR) affect obesity risk factors in children?
Conclusion
The study suggests that the RMR/BW ratio and dietary fat/retinol intake should be considered in precision medicine approaches for preventing obesity in children.
Supporting Evidence
- The OB group showed greater increases in RMR, BMI, WC, and SBP compared to the non-OB group.
- High retinol intake appeared to reduce obesity risk in children with certain DNAJC6 mutations.
- Changes in RMR/BW were significantly correlated with decreased BMI risk in major alleles of DNAJC6 SNPs.
Takeaway
This study looked at how a specific gene might affect weight in kids. It found that kids with certain gene changes might gain more weight and need to watch what they eat.
Methodology
The study followed 807 children over three years, measuring their weight, diet, and genetic factors related to obesity.
Potential Biases
Potential bias due to parental refusal to participate and reliance on self-reported dietary intake.
Limitations
The study used anthropometric measurements instead of more precise methods like DEXA for body composition and relied on predictive methods for estimating RMR.
Participant Demographics
Children aged 8-9 years, with a final sample of 512 (372 boys and 140 girls).
Statistical Information
P-Value
0.0013
Confidence Interval
1.068–6.274
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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