Genetic Analysis of Autoimmune Genes in Uveitis Patients
Author Information
Author(s): Martin Tammy M., Bye Louise, Modi Neil, Stanford Miles R., Vaughan Robert, Smith Justine R., Wade N. Kevin, Mackensen Friederike, Suhler Eric B., Rosenbaum James T., Wallace Graham R.
Primary Institution: Oregon Health & Science University
Hypothesis
Do polymorphisms in PTPN22 and CTLA-4 genes contribute to acute anterior uveitis (AAU)?
Conclusion
The study found no association between SNPs in PTPN22 and CTLA-4 and acute anterior uveitis.
Supporting Evidence
- No significant association was found between the SNPs and AAU.
- The study included a well-defined cohort of AAU patients and matched controls.
- The findings suggest AAU may be more autoinflammatory than autoimmune.
Takeaway
The researchers looked at genes that might cause eye inflammation but found that they don't seem to play a role in this condition.
Methodology
SNPs in PTPN22 and CTLA-4 were analyzed in 140 AAU patients and 92 healthy controls using SSP-PCR.
Limitations
The study only tested specific SNPs and did not include other potential genetic factors.
Participant Demographics
140 AAU patients (78 female, 62 male), primarily Caucasian; 92 healthy controls (54 female, 38 male), mostly Caucasian.
Statistical Information
P-Value
p=0.217
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