Kynurenine to Tryptophan Ratio in Sepsis and Its Effects
Author Information
Author(s): Darcy Christabelle J., Davis Joshua S., Woodberry Tonia, McNeil Yvette R., Stephens Dianne P., Yeo Tsin W., Anstey Nicholas M.
Primary Institution: Global Health Division, Menzies School of Health Research and Charles Darwin University
Hypothesis
IDO activity in sepsis would be related to plasma interferon-γ, interleukin-10, T cell lymphopenia and impairment of microvascular reactivity.
Conclusion
Increased IDO activity in sepsis is associated with dysregulated immune responses and impaired microvascular reactivity.
Supporting Evidence
- The plasma KT ratio was increased in sepsis compared to controls.
- In response to treatment of severe sepsis, the median KT ratio decreased significantly.
- IDO activity was significantly increased in sepsis patients compared to controls.
Takeaway
When people get very sick from infections, their bodies break down a substance called tryptophan into something called kynurenine, which can make it harder for their immune system to work properly.
Methodology
An observational cohort study of 80 sepsis patients and 40 hospital controls, measuring plasma amino acids and microvascular reactivity.
Limitations
The study did not directly measure IDO expression.
Participant Demographics
80 sepsis patients (50 severe and 30 non-severe) and 40 hospital controls.
Statistical Information
P-Value
p<0.0001
Confidence Interval
IQR 64–235
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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