TNF- α augments intratumoural concentrations of doxorubicin in TNF- α -based isolated limb perfusion in rat sarcoma models and enhances anti-tumour effects
2000
TNF-α Boosts Doxorubicin in Tumor Treatment
publication
Evidence: moderate
Author Information
Author(s): van der Veen A H, de Wilt J H W, Eggermont A M M, van Tiel S T, Seynhaeve A L B, ten Hagen T L M
Primary Institution: Department of Surgical Oncology, University Hospital Rotterdam/Daniel den Hoed Cancer Center
Hypothesis
Does TNF-α enhance the effectiveness of doxorubicin in treating sarcoma in rats?
Conclusion
The combination of TNF-α and doxorubicin significantly improves tumor regression in rat models.
Supporting Evidence
- The addition of TNF-α resulted in tumor regression in 54% of BN175-fibrosarcoma cases and 100% of ROS-1 osteosarcoma cases.
- Doxorubicin accumulation in tumor tissue increased 3.1-fold in BN175 and 1.8-fold in ROS-1 when combined with TNF-α.
Takeaway
When treating tumors in rats, adding TNF-α to doxorubicin helps the medicine work better.
Methodology
The study used isolated limb perfusion with doxorubicin and TNF-α in rat sarcoma models to assess tumor response.
Participant Demographics
Rat sarcoma models were used in the study.
Digital Object Identifier (DOI)
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