Monoclonal antibody ONS-M21 recognizes integrin α3 in gliomas and medulloblastomas
1999
Monoclonal Antibody ONS-M21 and Its Role in Gliomas and Medulloblastomas
publication
Author Information
Author(s): Kishima H, Shimizu K, Tamura K, Miyao Y, Mabuchi E, Tominaga E, Matsuzaki J, Hayakawa T
Primary Institution: Osaka University Medical School
Hypothesis
The ONS-M21 antibody recognizes integrin α3 in gliomas and medulloblastomas.
Conclusion
The ONS-M21 antibody may be useful for diagnosing gliomas and medulloblastomas due to its specific reaction with integrin α3.
Supporting Evidence
- The ONS-M21 antibody specifically recognizes an antigen on glioma and medulloblastoma cells.
- The identified 140-kDa protein has sequences related to integrin α3.
- Integrin α3 mRNA levels correlate with the malignancy grade of tumors.
Takeaway
A special antibody can help doctors find certain brain tumors by recognizing a specific protein that those tumors have.
Methodology
The study involved purifying and identifying a 140-kDa protein and analyzing mRNA from surgical specimens.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website