Study of HIV-1 CRF28_BF and CRF29_BF in Brazil
Author Information
Author(s): Ristic Natalia, Zukurov Jean, Alkmim Wagner, Diaz Ricardo Sobhie, Janini Luiz Mario, Chin Mario P. S.
Primary Institution: Aaron Diamond AIDS Research Center, The Rockefeller University
Hypothesis
What are the evolutionary and demographic histories of HIV-1 CRF28_BF and CRF29_BF in Brazil?
Conclusion
HIV-1 recombinants CRF28_BF and CRF29_BF are still circulating in Brazil but show a decreasing prevalence in the AIDS epidemic.
Supporting Evidence
- HIV-1 CRF28_BF and CRF29_BF were identified in Brazil in 1999.
- The effective number of infections by these recombinants grew exponentially for five years after their emergence.
- The demographic pattern of both recombinants resembles those previously reported for CRF31_BC.
- Both CRF28_BF and CRF29_BF did not exhibit a strong founder effect.
- The study provides insights into the contributions of HIV-1 recombinants to the AIDS epidemic in South America.
Takeaway
This study looks at two types of HIV that mix together in Brazil and shows that they are becoming less common over time.
Methodology
The study used a Bayesian coalescent framework to analyze HIV-1 sequences and estimate their evolutionary history.
Limitations
The study relies on data up to 2007, which may not reflect the current state of the HIV epidemic in Brazil.
Participant Demographics
The study included HIV-1 sequences from patients attending treatment centers in Sao Paulo, Brazil.
Statistical Information
Confidence Interval
(1.72×10−3–3.46×10−3)
Digital Object Identifier (DOI)
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