Study of p63 in Breast Lesions
Author Information
Author(s): Muacevic Alexander, Adler John R, Velamala Pavani, Dogga Sunil Kumar, Tandyala Naresh, Dhavala Murali Mohana Rao, Pappala Priyanka, Sanuvada V R Raja Sekhar
Primary Institution: Great Eastern Medical School and Hospital, Srikakulam, IND
Hypothesis
Does p63 expression help distinguish between benign and malignant breast lesions?
Conclusion
p63 is a reliable immunohistochemical marker that can help differentiate between benign and malignant breast lesions.
Supporting Evidence
- All benign cases showed positive p63 expression, while the majority of malignant cases were negative.
- The sensitivity of p63 in distinguishing benign from malignant lesions was found to be 100%.
- The study included a total of 86 cases, with 46 benign and 40 malignant lesions.
- Statistically significant differences in p63 expression were observed between benign and malignant lesions.
- p63 can serve as a reliable marker for differentiating between benign and malignant breast lesions.
Takeaway
This study looked at how a special marker called p63 can tell if a breast lump is harmless or harmful. It found that p63 is very good at helping doctors make this decision.
Methodology
This cross-sectional study analyzed 86 cases of breast disease using immunohistochemical staining for p63.
Limitations
The small sample size may limit the broader applicability of the results.
Participant Demographics
The study included 81 females and 5 males, with ages ranging from 18 to 80 years, and the average age at presentation was 40.8 years.
Statistical Information
P-Value
<0.00001
Statistical Significance
p<0.00001
Digital Object Identifier (DOI)
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