Adipose-Derived Stem Cells Help Nerve Healing
Author Information
Author(s): Lopatina Tatiana, Kalinina Natalia, Karagyaur Maxim, Stambolsky Dmitry, Rubina Kseniya, Revischin Alexander, Pavlova Galina, Parfyonova Yelena, Tkachuk Vsevolod
Primary Institution: Lomonosov Moscow State University, Moscow, Russia
Hypothesis
Adipose-derived stem cells (ASCs) stimulate repair of crushed peripheral nerves and induce nerve sprout growth by producing neurotrophic growth factors and myelin sheath components.
Conclusion
The study shows that ASCs can enhance nerve repair and growth through the production of BDNF.
Supporting Evidence
- ASCs stimulate the regeneration of nerves in innervated mice's limbs.
- BDNF neutralizing antibodies abrogated the stimulatory effects of ASCs on nerve growth.
- ASCs express numerous genes of neurotrophins and extracellular matrix proteins required for nerve growth.
- Transplantation of ASCs accelerated functional recovery of motor and sensory nerves.
Takeaway
Scientists found that special cells from fat can help heal damaged nerves and make them grow better.
Methodology
The study used in vivo models of nerve injury and growth, analyzing gene expression patterns in ASCs.
Participant Demographics
15 female donors for human ASCs; 8-9 week old male mice for experiments.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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