Endocrine Disorders Following Treatment of Childhood Brain Tumours
Author Information
Author(s): E.A. Livesey, P.C. Hindmarsh, C.G.D. Brook, A.C. Whitton, H.J.G. Bloom, J.S. Tobias, J.N. Godlee, J. Britton
Primary Institution: Endocrine Unit, The Middlesex Hospital, London
Hypothesis
What are the long-term endocrine effects of treatment on children with brain tumours?
Conclusion
The study found that almost all children treated for brain tumours experienced growth hormone insufficiency and other endocrine disorders, highlighting the need for long-term follow-up.
Supporting Evidence
- 140 of 144 patients had evidence of growth hormone insufficiency.
- Primary thyroid dysfunction was found in 23% of children treated with craniospinal irradiation.
- 35% of girls treated with spinal irradiation had primary ovarian dysfunction.
- Chemotherapy increased the incidence of thyroid dysfunction significantly.
Takeaway
Kids who get treated for brain tumors often have problems with their hormones later on, which can affect their growth and health.
Methodology
The study involved 144 children treated for brain tumours, assessing their endocrine function through various hormonal tests and follow-ups.
Limitations
The study may not account for all potential endocrine dysfunctions, especially in prepubertal children.
Participant Demographics
77 boys and 67 girls, median age at treatment 6.7 years.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.01
Want to read the original?
Access the complete publication on the publisher's website