Metabolic Adaptation with Caloric Restriction
Author Information
Author(s): Leanne M. Redman, Leonie K. Heilbronn, Corby K. Martin, Lilian de Jonge, Donald A. Williamson, James P. Delany, Eric Ravussin
Primary Institution: Pennington Biomedical Research Center
Hypothesis
Caloric restriction will reduce energy metabolism in excess of the loss of metabolic mass.
Conclusion
Caloric restriction leads to metabolic and behavioral adaptations, resulting in decreased physical activity levels.
Supporting Evidence
- Caloric restriction resulted in a significant reduction in total daily energy expenditure.
- Participants on caloric restriction showed decreased physical activity levels.
- Metabolic adaptation was observed in response to caloric restriction.
Takeaway
When people eat less, their bodies use less energy, which can make it harder to keep off weight.
Methodology
Participants were randomized into four groups for 6 months, with measurements of body composition and energy expenditure taken at baseline, 3 months, and 6 months.
Potential Biases
Participants were excluded if they had a history of obesity or other health issues, which may limit generalizability.
Limitations
The sample size may limit the ability to detect significant changes at 6 months.
Participant Demographics
48 healthy, overweight men and women aged 25-50 years.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website