Study of Chromosome 22 Abnormalities in Human Embryos
Author Information
Author(s): Mantzouratou Anna, Mania Anastasia, Apergi Marianna, Laver Sarah, Serhal Paul, Delhanty JDA
Primary Institution: UCL Centre for PGD, Institute for Women's Health, University College London
Hypothesis
What are the meiotic and mitotic behaviors of a ring/deleted chromosome 22 in human embryos?
Conclusion
The study provided insights into the instability and behavior of ring chromosome 22 during early embryonic development.
Supporting Evidence
- The couple underwent two cycles of PGD with a total of 12 embryos biopsied.
- No embryos were completely normal or balanced for chromosome 22 by day 5.
- The study is the first reported PGD attempt for a ring chromosome abnormality.
Takeaway
Scientists looked at embryos to see how a special type of chromosome behaves, and they found that it often doesn't work right.
Methodology
The study involved preimplantation genetic diagnosis (PGD) using fluorescence in situ hybridization (FISH) on embryos and lymphocytes.
Limitations
No embryos suitable for transfer were found in either PGD cycle.
Participant Demographics
The female participant was a 37-year-old carrier of a ring chromosome 22.
Digital Object Identifier (DOI)
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