Alginate Coated Chitosan Microparticles for Vaccine Delivery
Author Information
Author(s): Li XingYi, Kong XiangYe, Shi Shuai, Zheng XiuLing, Guo Gang, Wei YuQuan, Qian ZhiYong
Primary Institution: State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, PR China
Hypothesis
Can alginate coating improve the stability and release behavior of chitosan microparticles for oral mucosal vaccines?
Conclusion
Alginate coated chitosan microparticles are effective for oral vaccine delivery, providing stability and controlled release of the model protein BSA.
Supporting Evidence
- The loading efficiency of BSA in chitosan microparticles was 60%.
- Alginate coating reduced the initial burst release of BSA from 84% to 40% in 8 hours.
- Alginate coating protected BSA from degradation in acidic conditions for at least 2 hours.
Takeaway
This study shows that coating chitosan microparticles with alginate helps protect vaccines from stomach acid and allows them to be released slowly in the body.
Methodology
Chitosan microparticles were prepared using ionic gelation, loaded with BSA, and then coated with alginate to enhance stability and control release.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website