Bacterial Inactivation of Wound Infection by Liquid Plasma
Author Information
Author(s): Kim Paul Y., Koo Yoon-Sun, Jung Il Gyo, Kim Jae Chul, Choi Gon Jun, Yu Myeong Yeol, Collins George J.
Primary Institution: Colorado State University
Hypothesis
Liquid plasma may have greater accessibility to bacterial crevices in a human skin model and provide a higher concentration of bactericidal species.
Conclusion
Liquid plasma treatment shows potential as an adjunct therapy for chronic wounds by significantly reducing bacterial load.
Supporting Evidence
- Plasma treatment resulted in a statistically significant 3.83-log10 decrease in colony forming units of S. aureus after 2 minutes.
- A 3-minute treatment of 24-hour biofilm culture showed a statistically significant 1.59-log10 reduction in bacterial load.
- Histological analysis indicated minimal changes in tissue morphology with 1 and 2-minute treatments.
Takeaway
This study shows that a special kind of plasma can help clean infections from wounds by killing bacteria without hurting the skin.
Methodology
The study used a reconstructed human skin model contaminated with Staphylococcus aureus and treated it with liquid plasma to measure bacterial inactivation.
Limitations
The study does not present evidence of biofilm formation and the effects of longer treatment durations on tissue viability were not fully explored.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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