Study on Signet Ring Colorectal Carcinoma in Pakistan
Author Information
Author(s): Muacevic Alexander, Adler John R, Zubair Muhammad, Akhtar Muhammad Anas Bin, Tayyab Zain, Kazim Sayed Moosa, Syed Aamir, Khattak Shahid, Tayyab Muhammad, Atiq Hafsa, Alauddin Muhammad, Afzaal Muhammad
Primary Institution: Shaukat Khanum Memorial Cancer Hospital and Research Centre
Hypothesis
What are the incidence, clinicopathological features, treatments, and outcomes of signet ring cell colorectal carcinoma in Pakistan?
Conclusion
Signet ring cell colorectal cancer (SRCC) manifests in Pakistan at a younger age and is diagnosed at a more advanced stage, often accompanied by peritoneal metastasis.
Supporting Evidence
- 214 cases of signet ring cell carcinoma were analyzed.
- 86% of patients were under 50 years old.
- 98% of cases were diagnosed at advanced stages T3 and T4.
- 12.6% of patients had distant metastasis at diagnosis.
- 51.5% of patients experienced peritoneal metastasis.
Takeaway
This study found that a rare type of colon cancer, called signet ring cell carcinoma, is more common in younger people in Pakistan and is often diagnosed late, making it harder to treat.
Methodology
The study analyzed 214 cases of primary signet ring cell carcinoma using clinical data from a hospital database and statistical tests.
Limitations
The study is a single-center retrospective analysis and lacks data on family history and molecular characteristics.
Participant Demographics
{"gender_distribution":{"male":165,"female":49},"age_distribution":{"under_50":184,"over_50":30},"comorbidities":{"yes":42,"no":172}}
Statistical Information
P-Value
0.020
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website