Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene

2008

Early Onset Lung Cancer and MDM2 Gene Polymorphism

Sample size: 1935 publication Evidence: moderate

Author Information

Author(s): Kirstin Mittelstrass, Wiebke Sauter, Albert Rosenberger, Thomas Illig, Maria Timofeeva, Norman Klopp, Hendrik Dienemann, Eckart Meese, Gerhard Sybrecht, Gabi Woelke, Mathias Cebulla, Maria Degen, Harald Morr, Peter Drings, Andreas Groeschel, Karsten Grosse Kreymborg, Karl Haeußinger, Gerd Hoeffken, Christine Schmidt, Bettina Jilge, Wilhelm Schmidt, You-Dschun Ko, Dagmar Taeuscher, Jenny Chang-Claude, Heinz-Erich Wichmann, Heike Bickeboeller, Angela Risch

Primary Institution: Helmholtz Center Munich, German Research Center for Environmental Health

Hypothesis

Does the MDM2 SNP309 polymorphism influence the risk of developing early onset lung cancer?

Conclusion

The MDM2 SNP309 is not significantly associated with lung carcinogenesis, but there may be gender-specific differences.

Supporting Evidence

The study included 635 lung cancer patients and 1300 healthy controls.
Conditional logistic models were used to assess the association between the MDM2 SNP309 and lung cancer risk.
No significant association was found between the MDM2 SNP309 and lung cancer.
Gender-specific differences were noted but not statistically significant.
The study had sufficient power to detect an odds ratio of 1.6.

Takeaway

This study looked at whether a specific gene change affects the risk of getting lung cancer at a young age, and it found that it doesn't seem to make a difference.