Genetic Variants Affecting Ivermectin Metabolism in Ghanaians
Author Information
Author(s): Kudzi William, Dodoo Alexander, Mills Jeremy
Primary Institution: University of Portsmouth and University of Ghana Medical School
Hypothesis
Polymorphisms in MDR1 and CYP3A genes may explain the suboptimal response to ivermectin in some patients.
Conclusion
The study identified significant differences in genetic variants between responders and suboptimal responders to ivermectin treatment.
Supporting Evidence
- MDR1 (3435T) variant allele frequency was higher in suboptimal responders (21%) compared to responders (12%).
- CYP3A4*1B, CYP3A5*3, and CYP3A5*6 alleles were detected at varied frequencies in the Ghanaian population.
- Significant differences in genotype frequencies were observed between responders and suboptimal responders.
Takeaway
Some people in Ghana may not respond well to ivermectin because of their genes, which can change how their bodies process the medicine.
Methodology
The study used PCR-RFLP to analyze genetic polymorphisms in 204 healthy individuals and 42 ivermectin-treated patients.
Limitations
The small sample size of ivermectin-treated individuals limits the generalizability of the findings.
Participant Demographics
204 healthy unrelated blood donors from Accra, Ghana, including 92 males and 112 females.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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