Using Benchtop MRI to Study Tumors in Mice
Author Information
Author(s): Caysa Henrike, Metz Hendrik, Mäder Karsten, Mueller Thomas
Primary Institution: Martin-Luther-University Halle-Wittenberg
Hypothesis
Can Benchtop-MRI provide sufficient image quality for monitoring tumor progression in mouse models?
Conclusion
Benchtop-MRI provides satisfactory image quality to visualize organs and tumors and to monitor tumor progression in mouse models.
Supporting Evidence
- Subcutaneous xenografts were easily identified as relative hypointense areas in NMR images.
- Monitoring of tumor progression evaluated by pixel extension analyses correlated with increasing tumor volume calculated by calliper measurement.
- Gd-BOPTA contrast agent injection improved differentiation between urinary tissues and organs.
Takeaway
Researchers used a new type of MRI to see tumors in mice, and it worked well enough to help them understand how the tumors grow.
Methodology
A prototype BT-MRI system was used to visualize organs and tumors in nude mouse xenograft models, with tumor progression analyzed through NMR images and calliper measurements.
Limitations
The study is limited by the low field strength and decreased magnet homogeneity of the BT-MRI system.
Participant Demographics
Eight week old male athymic-nude Foxn1 nu/nu mice were used.
Digital Object Identifier (DOI)
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