Hepatocyte growth factor/scatter factor enhances the invasion of mesothelioma cell lines and the expression of matrix metalloproteinases
2000
Hepatocyte Growth Factor Enhances Mesothelioma Cell Invasion
publication
Author Information
Author(s): Harvey P, Clark I M, Jaurand M-C, Warn R M, Edwards D R
Primary Institution: School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
Hypothesis
Does hepatocyte growth factor/scatter factor enhance the invasion of mesothelioma cell lines?
Conclusion
Hepatocyte growth factor/scatter factor significantly enhances the invasion and adhesion of mesothelioma cell lines while regulating matrix metalloproteinases.
Supporting Evidence
- HGF/SF acts as a strong chemoattractant for human mesothelioma cell lines.
- HGF/SF enhances cell adhesion to and invasion into Matrigel.
- Mesothelioma cell lines synthesized matrix metalloproteinases critical for tumor progression.
- HGF/SF stimulated the expression of MMP-1, 9 and MT1-MMP.
Takeaway
Hepatocyte growth factor helps mesothelioma cells move and invade more easily, which is important for understanding cancer spread.
Methodology
The study involved testing the effects of exogenous HGF/SF on human mesothelioma cell lines in terms of adhesion and invasion into Matrigel.
Digital Object Identifier (DOI)
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