Impaired Genome Maintenance Suppresses the Growth Hormone–Insulin-Like Growth Factor 1 Axis in Mice with Cockayne Syndrome
2008
Genome Maintenance and Growth Hormone in Mice
publication
Author Information
Author(s): van der Pluijm I, Garinis GA, Brandt RMC, Gorgels TGMF, Wijnhoven SW, Hoeijmakers J. H. J.
Hypothesis
Impaired genome maintenance affects the growth hormone-insulin-like growth factor 1 axis in mice with Cockayne syndrome.
Conclusion
The study found that impaired genome maintenance suppresses the growth hormone-insulin-like growth factor 1 axis in mice with Cockayne syndrome.
Takeaway
When mice have problems keeping their DNA healthy, it can stop their growth hormone from working properly.
Potential Biases
One author had a competing interest due to ownership of shares in a related company.
Digital Object Identifier (DOI)
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