HPV 16 Antibodies in Cancer Patients
Author Information
Author(s): Van Doornum G J J, Korse C M, Buning-Kager J C G M, Bonfrer J M G, Horenblas S, Taal B G, Dillner J
Primary Institution: Antoni van Leeuwenhoek Hospital and Netherlands Cancer Institute
Hypothesis
The study aims to determine the seroprevalence of antibodies against HPV 16 in patients with various carcinomas.
Conclusion
The study found a strong association between HPV 16 L1 antibodies and cervical and penile squamous cell carcinomas, but no significant association with oesophageal, tongue, laryngeal, or vaginal carcinomas.
Supporting Evidence
- HPV 16 antibodies were found in 47% of cervical squamous carcinoma patients.
- 38% of penile carcinoma patients tested positive for HPV 16 antibodies.
- 33% of oropharyngeal carcinoma patients had HPV 16 antibodies.
Takeaway
The study looked at blood samples from cancer patients to see if they had antibodies against a virus called HPV 16, which is linked to some cancers.
Methodology
The study used serological assays to test for HPV 16 antibodies in serum samples from cancer patients and matched controls.
Potential Biases
Selection bias may arise from using hospital patients as controls.
Limitations
The study is retrospective and relies on hospital-based controls, which may not represent the general population.
Participant Demographics
The study included 706 patients with various carcinomas, with a mean age of 61.9 years.
Statistical Information
P-Value
<0.001
Confidence Interval
(1.9–8.4)
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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