Comparing Anticoagulants in Older Adults with Atrial Fibrillation
Author Information
Author(s): Yaguchi Daichi, Sera Shoji, Okada Akira, Nishimura Yuki, Tamaru Satoshi, Nagai Naomi
Primary Institution: Musashino University
Hypothesis
Is the efficacy and safety of direct oral anticoagulants (DOACs) comparable to warfarin in older Japanese patients with nonvalvular atrial fibrillation?
Conclusion
The overall efficacy and safety of DOACs were generally comparable to warfarin in older Japanese patients with nonvalvular atrial fibrillation.
Supporting Evidence
- The incidence rates of bleeding events for individual DOACs were comparable to those for warfarin.
- A history of vascular disorders was identified as a risk factor for bleeding events in both treatment groups.
- Dabigatran showed a significantly lower incidence of systemic embolic events compared to warfarin.
Takeaway
This study looked at older people in Japan taking blood thinners for heart issues and found that newer medications work just as well as the older ones.
Methodology
This was a multicenter observational retrospective cohort study using data from the Mie-Life Innovation Promotion Center Database to analyze bleeding and systemic embolic events in patients aged 75 and older.
Potential Biases
The study may have been influenced by the lack of randomization and potential confounding variables not accounted for in the dataset.
Limitations
The study included non-randomized data, potential incomplete follow-up, and missing event data, and did not verify endpoint data.
Participant Demographics
Patients were aged 75 years and older, with a mean age around 82 years, and included both men and women.
Statistical Information
P-Value
p < 0.01
Confidence Interval
95% CI: 1.16–2.88
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website