Structural Similarity of Genetically Interacting Proteins
Author Information
Author(s): Dror Oranit, Schneidman-Duhovny Dina, Shulman-Peleg Alexandra, Nussinov Ruth, Wolfson Haim J, Sharan Roded
Primary Institution: Tel Aviv University
Hypothesis
Structural similarity may reveal genetic interactions that cannot be detected at the sequence level.
Conclusion
Structural similarity is an important property that can explain and predict genetic interactions.
Supporting Evidence
- 7–10% of all known interactions in yeast involve structurally similar proteins.
- 14% of all known interactions in worm involve structurally similar proteins.
- Structural features identified are predictive of genetic interactions.
Takeaway
Scientists studied how similar the shapes of proteins are to understand how they interact with each other. They found that many interactions happen between proteins that look alike.
Methodology
A genome-scale structural comparison among protein pairs in yeast and worm was performed, involving over a million structural alignments.
Limitations
The study may underestimate the utility of structural information in genetic interaction prediction due to high rates of false negatives and incomplete structural information.
Statistical Information
P-Value
p < 1.2 e – 9
Statistical Significance
p < 0.05
Digital Object Identifier (DOI)
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