Renal cell carcinoma induces interleukin 10 and prostaglandin E2 production by monocytes
1999
Renal Cell Carcinoma and Immune Response
Sample size: 21
publication
Evidence: moderate
Author Information
Author(s): Ménétrier-Caux C, Bain C, Favrot M C, Duc A, Blay J Y
Primary Institution: Centre Léon Bérard
Hypothesis
Renal cell carcinoma induces the production of immunosuppressive factors by monocytes.
Conclusion
Renal cell carcinoma induces the production of IL-10, PGE2, and TNF-α by monocytes, which impairs their ability to present antigens.
Supporting Evidence
- IL-10 was detectable in 10 of 21 tumor samples tested.
- RCC conditioned medium induced IL-10 and PGE2 production by monocytes.
- The production of IL-10 was dependent on TNF-α and PGE2.
Takeaway
Kidney cancer makes certain immune cells produce substances that can weaken the immune response, making it harder for the body to fight the cancer.
Methodology
Immunohistochemistry was used to detect IL-10 in tumor samples, and the effects of RCC conditioned medium on immune cells were assessed.
Digital Object Identifier (DOI)
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