OrthoDB and BUSCO update: annotation of orthologs with wider sampling of genomes
2024
Update on OrthoDB and BUSCO for Gene Annotation
Sample size: 5827
publication
Evidence: high
Author Information
Author(s): Tegenfeldt Fredrik, Kuznetsov Dmitry, Manni Mosè, Berkeley Matthew, Zdobnov Evgeny M, Kriventseva Evgenia V
Primary Institution: University of Geneva
Conclusion
The update to OrthoDB significantly enhances global coverage of genomic diversity, improving the accuracy of gene annotations.
Supporting Evidence
- The update expands OrthoDB to include 5827 eukaryotic genomes.
- Annotated genes increased from 100 to 162 million.
- OrthoDB provides evolutionary and functional annotations for comparative genomic studies.
- The BUSCO tool has been updated to enhance accuracy and broaden taxonomic coverage.
Takeaway
This study updates a database that helps scientists understand genes from different species by comparing them, making it easier to learn about new genomes.
Methodology
The update includes expanded genomic data and improved tools for gene annotation and ortholog identification.
Limitations
The accuracy of functional annotations may contain inaccuracies due to data aggregation.
Digital Object Identifier (DOI)
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