Study Protocol for COVID-19 Breakthrough Infections and Vaccine Response in Healthcare Workers in Bangladesh
Author Information
Author(s): Hassan Md. Zakiul, Basher Ahamed Khairul, Rahman Mohammed Ziaur, Bhuiyan Taufiqur Rahman, Chowdhury Fahmida, Hossain Md. Kamal, Rahman Aninda, Islam Md. Nazmul, M. Duca Lindsey, Kaydos-Daniels Susan Cornelia, A. Dahl Benjamin, Qadri Firdausi, Ortiz Nancy
Primary Institution: International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh
Hypothesis
This study aims to monitor SARS-CoV-2 breakthrough infections, the emergence of new variants, and host immune response during the peri-infection period among healthcare workers.
Conclusion
The study will provide valuable information on COVID-19 breakthrough infections and the durability of anti-SARS-CoV-2 antibodies among healthcare workers following vaccination.
Supporting Evidence
- COVID-19 has infected over 762 million people globally.
- Healthcare workers have experienced a significantly higher rate of COVID-19 morbidity compared to the general population.
- Only 60% of healthcare workers have completed their COVID-19 booster doses.
Takeaway
This study is looking at how well COVID-19 vaccines work for healthcare workers and if they still get sick after being vaccinated.
Methodology
The study will follow healthcare workers biweekly for COVID-19 symptoms and collect respiratory swabs and blood samples to assess breakthrough infections and immune responses.
Limitations
The results may not be generalizable to other populations outside of healthcare workers.
Participant Demographics
Healthcare workers aged above 18 years from various health facilities across four administrative divisions in Bangladesh.
Digital Object Identifier (DOI)
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