Antibody Dependent Enhancement of Enterovirus 71 Infection
Author Information
Author(s): Han Jian-Feng, Cao Rui-Yuan, Deng Yong-Qiang, Tian Xue, Jiang Tao, Qin E-De, Qin Cheng-Feng
Primary Institution: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, PR China
Hypothesis
The presence of sub-neutralizing antibodies enhances Enterovirus 71 (EV71) infection severity.
Conclusion
The study found that sub-neutralizing antibodies can enhance EV71 infection and increase mortality in mice.
Supporting Evidence
- Sub-neutralizing antibodies were shown to enhance EV71 infection in THP-1 cells.
- In a mouse model, lower concentrations of IVIG increased mortality from EV71 infection.
- Previous asymptomatic EV71 infection increased mortality in subsequent infections.
Takeaway
If kids have some antibodies from a previous infection, it can make them sicker if they get the virus again.
Methodology
The study used in vitro assays with THP-1 cells and in vivo experiments with suckling mice to assess the effects of sub-neutralizing antibodies on EV71 infection.
Potential Biases
Potential bias in the interpretation of results due to the use of specific antibody preparations.
Limitations
The study primarily used mouse models, which may not fully replicate human responses.
Participant Demographics
Suckling mice were used for in vivo experiments.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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