Nucleosomes and Tumor Markers in Colorectal Cancer
Author Information
Author(s): Jehad M Al-Shuneigat, Samir S Mahgoub, Fazlul Huq
Primary Institution: Mu'tah University, Al Karak, Jordan; The University of Sydney, Australia
Hypothesis
The study aims to compare the serum levels of nucleosomes, carcinoembryonic antigen (CEA), and CA 19-9 as apoptotic markers in colorectal carcinoma.
Conclusion
Serum levels of nucleosomes provide a highly sensitive and specific apoptotic marker for colorectal carcinoma.
Supporting Evidence
- Nucleosomes showed a significant increase in patients with poorly differentiated tumors compared to well differentiated tumors.
- CEA levels did not show significant increases in poorly differentiated tumors.
- Nucleosomes provide a better discrimination between control subjects and patients than CEA and CA 19-9.
Takeaway
Doctors can use a blood test to check for nucleosomes, which can help find colorectal cancer early.
Methodology
The study included 30 subjects, with blood samples collected to measure serum levels of nucleosomes, CEA, and CA 19-9.
Limitations
The study had a small sample size and was limited to a specific population.
Participant Demographics
24 colorectal carcinoma patients (10 females, 14 males) and 6 normal subjects as a control group.
Statistical Information
P-Value
0.041
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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