Early Onset Active Inflammatory Bowel Disease Is Associated With Psychiatric Comorbidities: A Multi-Network Propensity-Matched Cohort Study

2024

Early Onset Active Inflammatory Bowel Disease and Psychiatric Comorbidities

Sample size: 16922 publication 10 minutes Evidence: high

Author Information

Author(s): Nadeem Ahmed MD, Sydney Donohue MD, Fatima Zehra Shah MD, Jaime Abraham Perez PhD, Elleson Harper BS, Preetika Sinh MD, Ruthvik Padival MD, Gregory Cooper MD, Jeffry Katz MD, Fabio Cominelli MD, PhD, Miguel Regueiro MD, Emad Mansoor MD

Primary Institution: Cleveland Clinic Foundation

Hypothesis

Patients with active IBD early in their disease course experience increased psychiatric disease severity, comorbid psychiatric diagnoses, and increased psychotropic and nonpsychotropic medication usage.

Conclusion

Active IBD shortly after the IBD diagnosis is associated with a higher incidence of psychiatric comorbidities.

Supporting Evidence

Patients with active IBD had significantly higher odds of developing major depressive disorder and anxiety disorder.
Patients with active IBD were more likely to use psychotropic medications, including antidepressants and antipsychotics.
Routine screening for mental health disorders is recommended for IBD patients due to high prevalence.

Takeaway

If someone gets inflammatory bowel disease (IBD) early on and it’s active, they are more likely to have mental health issues and need medicine for it.