Anticonvulsant Effects of Passion Flower Extract in Mice
Author Information
Author(s): Nassiri-Asl Marjan, Shariati-Rad Schwann, Zamansoltani Farzaneh
Primary Institution: Qazvin University, Iran
Hypothesis
Pasipay would show anticonvulsive effects in a PTZ model, potentially due to several mechanisms.
Conclusion
Pasipay could be useful for treating absence seizures, likely related to its effects on GABAergic and opioid systems.
Supporting Evidence
- Pasipay at 0.4 mg/kg prolonged seizure onset time and decreased duration compared to saline.
- At 0.4 mg/kg, Pasipay provided 100% seizure and mortality protection.
- Flumazenil and naloxone suppressed the anticonvulsant effects of Pasipay.
Takeaway
This study found that a plant extract called Pasipay can help stop seizures in mice, which might be helpful for people with epilepsy.
Methodology
Mice were given different doses of Pasipay before being induced with seizures using PTZ, and various measurements were taken.
Limitations
Further studies are needed to investigate the exact mechanisms of Pasipay's effects.
Participant Demographics
Male BALB/c mice, 25–30 g.
Statistical Information
P-Value
0.001
Confidence Interval
0.156, 0.342
Statistical Significance
p < 0.001
Digital Object Identifier (DOI)
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