Monitoring Tumor Treatment with MRI
Author Information
Author(s): Morgan B, Utting J F, Higginson A, Thomas A L, Steward W P, Horsfield M A
Primary Institution: University of Leicester
Hypothesis
Dynamic contrast-enhanced MR imaging (DCE-MRI) may act as a biomarker for successful cancer therapy.
Conclusion
The study demonstrates that a single slice DCE-MRI technique is feasible and can effectively monitor tumor treatment.
Supporting Evidence
- The reproducibility study showed a coefficient of variation (CoV) of 19.1% for Ktrans.
- The individual repeatability was 30.6% for Ktrans for tumors greater than 3 cm in diameter.
- The method is sensitive to a treatment effect of greater than 18%.
Takeaway
This study shows a new way to use MRI to see how well cancer treatment is working by looking at how tumors react to a special dye.
Methodology
The study involved DCE-MRI scans of patients with advanced cancers, performed without treatment, to assess the reproducibility of the imaging technique.
Limitations
One patient was excluded due to incorrect positioning of the imaging slice.
Participant Demographics
Patients with advanced cancers, including colorectal cancers with liver metastases.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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