Study on p75NTR Positive Cells in Esophageal Cancer
Author Information
Author(s): Huang Sheng-Dong, Yuan Yang, Liu Xiao-Hong, Gong De-Jun, Bai Chen-Guang, Wang Feng, Luo Jun-Hui, Xu Zhi-Yun
Primary Institution: Institute of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, PR China
Hypothesis
The study investigates the expression of p75NTR in esophageal squamous cell carcinoma (ESCC) and explores the biological properties of p75NTR+ cells.
Conclusion
p75NTR+ cells exhibit characteristics of cancer stem cells, including self-renewal and resistance to chemotherapy.
Supporting Evidence
- p75NTR was mainly found in immature cells and absent in terminally differentiated cells.
- p75NTR+ cells showed higher expression of Bmi-1, associated with self-renewal.
- p75NTR+ cells were more resistant to DDP and had lower CTR1 expression.
Takeaway
Some cells in esophageal cancer can grow and resist treatment better than others, which might help explain why some cancers come back after treatment.
Methodology
The study used immunohistochemistry, fluorescence-activated cell sorting, and various assays to analyze p75NTR+ and p75NTR- cells from ESCC cell lines.
Potential Biases
Potential bias in patient selection and the interpretation of immunohistochemical results.
Limitations
The study is limited to a specific population and may not be generalizable to all esophageal cancer patients.
Participant Demographics
100 patients with histopathologically confirmed ESCC, no prior chemotherapy or radiotherapy.
Statistical Information
P-Value
0.008 for age correlation, 0.004 for tumor diameter, 0.001 for pathological grade.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website