MICROBIOME-KIDNEY METABOLISM PROVIDES INSIGHT INTO THE MECHANISM OF ICARIIN ALLEVIATES AGING IN OLDER FEMALE MICE
2024
Icariin and Aging in Older Female Mice
Sample size: 12
publication
Evidence: moderate
Author Information
Author(s): Li Xiaoang, Zhang Yiming, Duan Liping
Primary Institution: Peking University Third Hospital
Hypothesis
Icariin can delay aging in older female mice by affecting gut microbiota and metabolism.
Conclusion
Icariin treatment in older female mice improved gut microbiota and increased kidney-protective metabolites.
Supporting Evidence
- Icariin increased the abundance of beneficial gut bacteria in older female mice.
- The levels of kidney-protective metabolites were significantly increased after icariin treatment.
Takeaway
Icariin helps older female mice stay healthier by changing their gut bacteria and improving kidney function.
Methodology
Older female mice were treated with icariin and their gut microbiome and kidney metabolites were analyzed.
Participant Demographics
C57BL/6J female mice, aged 8 weeks and 24 months.
Digital Object Identifier (DOI)
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