The asialoglycoprotein receptor in liver cancer cells
Author Information
Author(s): Trerè D, Fiume L, Giorgi L Badiali De, Stefano G Di, Migaldi M, Derenzini M
Primary Institution: Servizio di Citopatologia, Policlinico S Orsola, Bologna, Italy
Hypothesis
The expression of the asialoglycoprotein receptor (ASGP-R) on human hepatocellular carcinoma (HCC) cells might be exploited to reduce the extrahepatic toxicity of DNA synthesis inhibitors.
Conclusion
The study found that the ASGP-R is present on the surface of DNA synthesizing cancer cells, particularly in well-differentiated HCCs.
Supporting Evidence
- 80% of well differentiated HCCs expressed ASGP-R on their surface.
- 20% of poorly differentiated HCCs expressed ASGP-R on their surface.
- The presence of ASGP-R on DNA synthesizing cancer cells was confirmed through immunohistochemical visualization.
Takeaway
Researchers looked at liver cancer cells to see if a specific receptor could help deliver drugs more safely. They found that many of these cancer cells have the receptor on their surface.
Methodology
Needle biopsies of HCC were evaluated, and immunohistochemical techniques were used to assess ASGP-R expression.
Digital Object Identifier (DOI)
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