New Tricks by an Old Dog
2008
Understanding C-Peptide and Its Role in Diabetes
Editorial
Evidence: moderate
Author Information
Author(s): Thomas Forst, John Wahren
Primary Institution: Johannes Gutenberg University and Karolinska Institute
Hypothesis
C-peptide may have biological effects beyond its role in insulin biosynthesis.
Conclusion
C-peptide administration may help prevent and treat microvascular complications in type 1 diabetes.
Supporting Evidence
- C-peptide has been shown to improve blood flow and nerve function in type 1 diabetes patients.
- Recent studies indicate that C-peptide may have its own biological effects.
- C-peptide administration could be beneficial when combined with insulin therapy.
Takeaway
C-peptide is important for making insulin and might also help with diabetes problems, like blood flow and nerve function.
Limitations
The lack of GMP-produced C-peptide suitable for human use limits extended clinical trials.
Digital Object Identifier (DOI)
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