Vitamin D and oestrogen receptor polymorphisms in developmental dysplasia of the hip and primary protrusio acetabuli – A preliminary study

2007

Vitamin D and Oestrogen Receptor Polymorphisms in Hip Disorders

Sample size: 166 publication Evidence: moderate

Author Information

Author(s): Birender Kapoor, Colin Dunlop, Charles Wynn-Jones, Anthony A Fryer, Richard C Strange, Nicola Maffulli

Primary Institution: Keele University School of Medicine

Hypothesis

Is there an association between developmental dysplasia of the hip (DDH) and primary protrusio acetabuli (PPA) with Vitamin D and oestrogen receptor polymorphisms?

Conclusion

The study suggests a possible correlation between gene polymorphisms in the oestrogen and vitamin D receptors and susceptibility to, and severity of DDH.

Supporting Evidence

The oestrogen receptor Xba I wild-type genotype was more common in the DDH group than controls.
Homozygosity for the mutant Taq I Vitamin D receptor t allele was associated with higher acetabular index.
The Pvu II pp oestrogen receptor genotype was associated with low centre edge angle.

Takeaway

This study looked at how certain genes might affect hip problems in people. They found some links, but more research is needed to be sure.

Methodology

The study included patients with DDH and PPA, and healthy controls, comparing genotype frequencies and examining the relationship between genotype and hip morphology.