Apocynin and Hyperbaric Oxygen Therapy Improve Kidney Function in Rats
Author Information
Author(s): Vukovic Andrija, Karanovic Danijela, Mihailovic-Stanojevic Nevena, Miloradovic Zoran, Brkic Predrag, Zivotic Maja, Nesovic Ostojic Jelena, Ivanov Milan, Kovacevic Sanjin, Vajic Una-Jovana, Jovovic Djurdjica, De Luka Silvio R.
Primary Institution: Institute of Pathological Physiology, Faculty of Medicine, University of Belgrade
Hypothesis
Apocynin and hyperbaric oxygen therapy may have protective effects on kidney structure and function in chronic kidney disease induced by 5/6 nephrectomy.
Conclusion
Both apocynin and hyperbaric oxygen therapy improved kidney function and structure in rats with chronic kidney disease.
Supporting Evidence
- All treatments significantly decreased mean arterial pressure compared to the Nx-L group.
- Apocynin treatment reduced protein loss and improved renal morphology.
- Hyperbaric oxygen therapy improved hypertension but did not significantly affect proteinuria levels.
- Combined treatment normalized blood pressure and improved kidney structure.
Takeaway
This study found that two treatments, apocynin and hyperbaric oxygen therapy, can help make sick kidneys work better in rats.
Methodology
Male Wistar rats were divided into five groups and treated with either apocynin, hyperbaric oxygen therapy, both, or none, with various assessments conducted after treatment.
Limitations
The study's findings may not fully translate to humans due to differences in animal models of chronic kidney disease.
Participant Demographics
Male Wistar rats, aged 6-7 weeks.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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