Foxp3 Gene Polymorphisms and Unexplained Recurrent Spontaneous Abortion
Author Information
Author(s): Wu Zaigui, You Zeshan, Zhang Cai, Li Zhuyu, Su Xiumei, Zhang Xiuming, Li Yinguang
Primary Institution: Sun Yat-Sen University
Hypothesis
Are functional polymorphisms at the Foxp3 loci associated with unexplained recurrent spontaneous abortion (URSA) in humans?
Conclusion
Functional polymorphisms of the Foxp3 gene may increase susceptibility to URSA in the Chinese Han population.
Supporting Evidence
- Women with URSA had reduced frequencies of CD4+CD25+Treg cells.
- Foxp3 is crucial for the development and function of Treg cells.
- Two polymorphisms in the Foxp3 gene were significantly associated with URSA.
- Patients with the G allele of rs2232365 had a higher risk of URSA.
Takeaway
Some changes in a specific gene can make it harder for women to stay pregnant, which is what this study looked at.
Methodology
The study genotyped four common polymorphisms of the Foxp3 gene in 146 URSA patients and 112 healthy women.
Potential Biases
Potential selection bias in the control group as they were derived from volunteers undergoing routine examinations.
Limitations
The study's findings may not be generalizable to populations outside the Chinese Han group.
Participant Demographics
146 URSA patients aged 22-40 years and 112 healthy women aged 23-44 years.
Statistical Information
P-Value
0.009 for rs2232365 A/G and 0.003 for rs3761548 A/C
Confidence Interval
(1.11, 2.32) for rs2232365 and (1.42, 6.26) for rs3761548
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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